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ea0029p992 | Growth hormone IGF axis - basic | ICEECE2012

C677T methylenetetrahydrofolate reductase gene polymorphism and colorectal neoplasms in acromegalic patients

Torre M. , Russo G. , Ragonese M. , Giandalia A. , Puglisi S. , De Menis E. , Arnaldi G. , Romanello G. , Cucinotta D. , Trimarchi F. , Cannavo S.

Introduction: Acromegalic patients have an increased risk of developing colorectal neoplasms (CN). A common polymorphism (C677T) in gene coding for methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism and in DNA synthesis, reparation and methylation, has been associated with CN risk in general population, but its role in acromegalic patients has never been explored yet.Aim: To investigate the contribution of MTHFR C677T polymorp...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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